Organization/Department 
Product Manager at Brinter Ltd 
Postdoctoral Researcher at Tampere University 

Biography 
D.Sc. (Tech.) Sanna Turunen works as a Product Manager at Brinter Ltd and as a Postdoctoral Researcher at Tampere University. She earned her M.Sc. (Tech.) degree in materials engineering in 2007 from the Tampere University of Technology (TUT), Finland. After graduation, she continued to work as a doctoral student in the Biomaterials and Tissue Engineering Group at TUT. Her research focussed on the fabrication of microstructure-based in vitro cell culture platforms with a laser-based 3D printing technique. She received her D.Sc. (Tech.) in biomedical sciences and engineering in 2017 from TUT. Her main research interests are biomaterials and additive manufacturing technologies for tissue engineering applications. 

Brinter Ltd.  is a Finnish 3D bioprinting company, which spanned out 31.12.2020 from 3DTech Ltd., a high-tech company specialized in 3D printing services. Brinter Ltd. is the culmination of years of 3D printing expertise and bioresearch done within 3DTech Ltd. Brinter provides comprehensive 3D printing and 3D bioprinting solutions and services for pharmaceutical, biotechnological and cosmetic industries, universities, and research facilities. Brinter® 3D printing platforms are modular and always custom-built according to customer-specific applications and needs. 

Title of Talk 
Cartilage Bioprinting Technology Development 

Abstract 
Chondral lesions constitute one of the major extrinsic risk factors for Osteoarthritis (OA), leading to significant societal and economic burden. OA is a highly prevalent condition that can result in disabling pain and loss of physical function. 

Horizon 2020 project RESTORE aims to develop and validate nanoenabled solutions in pre-clinical animal models for personalised cartilage regeneration. Different strategies are undertaken to overcome the current challenges and unmet clinical necessities in order to design the most efficient solution towards cartilage repair. RESTORE is building tailored nanocarriers based on polymeric nanobiomaterials, designed to modulate undesirable biological events (inflammation, proteolytic degradation, and bacterial infection), and remotely stimuli-responsive nanobiomaterials to enhance cartilage repair. 

Smart 3D matrices for severe and mild chondral lesions are created by integrating nanobiomaterials in COPLA® Scaffold (severe lesions) already present in the animal health market and in bioink used for bioprinting of personalised cartilage tissue (mild lesions). 

Brinter’s role in the RESTORE project is to facilitate the development of 3D bioprinter technology towards cartilage printing by implementing novel printing modalities into the bioprinting platform. The process also involves optimisation of the bioink composition and printing protocols.